Precipitative Coating of Calcium Phosphate on Microporous Silica–Titania Hybrid Particles in Simulated Body Fluid

Titania and silica have been recognized as potential drug delivery system (DDS) carriers. For this application, controllable biocompatibility the suppression of initial burst are required, which can be provided by a calcium phosphate (CP) coating. However, it is difficult to control morphology CP coating on surface carrier particles owing homogeneous nucleation CP. In study, we report development CP-coating method that homogeneously corresponds shapes silica–titania (SiTi) porous nanoparticles. We also demonstrate controlled roughness coatings could achieved in SBF using SiTi nanoparticles with well-defined spherical shape, uniform size, tunable nanoporous structure. The precipitation was performed mono-dispersed different Si/Ti molar ratios pore sizes. size distribution found significantly affect immersion; surfaces bimodal sizes 0.7 1.1–1.2 nm became rough after precipitation, while those unimodal remained smooth, indicating these two serve sites lead morphologies.